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Hepatic vein obstruction (Budd-Chiari)

Definition

Hepatic vein obstruction is a blockage of the vein, which carries blood away from the liver.

Causes

Hepatic vein obstruction prevents blood from flowing out of the liver and back to the heart. This blockage can cause liver damage. Obstruction of this vein can be caused by a or growth pressing on the vessel, or by a clot in the vessel (hepatic vein thrombosis).

Most often, it is caused by conditions that make blood clots more likely to form, including:

  • Abnormal growth of cells in the bone marrow (myeloproliferative disorders)
  • Cancers
  • Chronic inflammatory or diseases
  • Infections
  • Inherited (hereditary) or acquired problems with blood clotting
  • Oral contraceptives
  • Pregnancy

    • Hepatic vein blockage is the most common cause of Budd-Chiari syndrome.

    Symptoms

    Symptoms include:

  • Abdominal swelling or stretching due to fluid in the abdomen
  • Pain in the right upper abdomen
  • Vomiting blood
  • Yellowing of the skin (jaundice)

    • Exams and Tests

    One of the signs is swelling of the abdomen from fluid buildup (). The liver is often swollen and tender.

    Tests include:

  • or
  • Doppler ultrasound of the liver veins
  • of the liver

    • Treatment

    Treatment varies, depending on the cause of the blockage.

    Your health care provider may recommend the following medicines:

  • Blood thinners (anticoagulants)
  • Clot-busting drugs (thrombolytic treatment)
  • Medicines to treat the liver disease, including ascites

    • Surgery may be recommended. This may involve:

  • and placement
  • Transjugular intrahepatic portosystemic shunt ()
  • Venous shunt surgery
  • Liver transplant

    • Possible Complications

    Hepatic vein obstruction can get worse and lead to and liver failure. This can be life threatening.

    When to Contact a Medical Professional

    Contact your provider if:

  • You have symptoms of hepatic vein obstruction
  • You are being treated for this condition and you develop new symptoms

    • References

    Kahi CJ. Vascular diseases of the gastrointestinal tract. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 134.

    Nery FG, Valla DC. Vascular diseases of the liver. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 85.

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    Contact Atlanta Obsetrics and Gynaecology at The Womens Center Millennium Hospital - 404-ATL-BABY

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    Review Date: 5/4/2022

    Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.