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Thyroid storm

Definition

Thyroid storm is a rare life-threatening condition of the thyroid gland. It develops in cases of untreated , or overactive thyroid (thyrotoxicosis).

The thyroid gland is located in the neck, just above where your collarbones meet in the middle.

Causes

Thyroid storm occurs in people with uncontrolled hyperthyroidism due to a major stress such as:

  • Trauma
  • Infection

    • Rarely, thyroid storm can be caused by radioactive iodine therapy for . This can occur even a week or more after treatment.

    Symptoms

    Symptoms are severe and may include any of the following:

  • Agitation
  • Change in alertness (consciousness)
  • Confusion
  • Diarrhea
  • Increased temperature
  • Pounding heart ()
  • Shaking
  • Sweating
  • Bulging eyeballs

    • Exams and Tests

    Your health care provider may suspect thyrotoxic storm based on:

  • A high systolic (top number) blood pressure reading with a lower diastolic (bottom number) blood pressure reading (wide pulse pressure)
  • A very high heart rate
  • A history of hyperthyroidism
  • An exam of your neck may find that your thyroid gland is enlarged ()

    • Blood tests are done to check the levels of the thyroid hormones , and .

    Other blood tests are done to check heart and kidney functions and to check for infection. Liver function tests provide added diagnosis and treatment information.

    Treatment

    Thyroid storm is a medical emergency. It is life threatening. Often, the person needs to be admitted to the intensive care unit. Treatment may include:

  • Oxygen therapy for breathing problems
  • Fluids for dehydration
  • Cooling blankets to return the body temperature to normal
  • Monitoring any excess fluid in older people with heart or kidney disease
  • Medicines to manage agitation
  • Medicine to slow the heart rate
  • Vitamins and glucose

    • The goal of treatment is to decrease thyroid hormone levels in the blood. Sometimes, high doses of iodine is given to try and stun the thyroid. Other medicines known as thionamides may be given to lower the hormone level in the blood. Beta blocker medicines are often given by vein (IV) to slow the heart rate, lower blood pressure, and block the effects of the thyroid hormone excess. In some severe cases, glucocorticoids (steroids) are given.

    Antibiotics are given in case of infection.

    Possible Complications

    Irregular heart rhythms () may occur. and fluid in the lungs () can develop rapidly and cause death.

    When to Contact a Medical Professional

    This is an emergency condition. Call 911 or the local emergency number if you have hyperthyroidism and experience symptoms of thyroid storm.

    Prevention

    To prevent thyroid storm, hyperthyroidism should be treated.

    References

    Hollenberg A, Wiersinga WM. Hyperthyroid disorders. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 12.

    Pearce EN, Hollenberg AN. Thyroid. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 207.

    Thiessen MEW. Thyroid and adrenal disorders. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 117.

    Weetman AP, Kahaly GJ. Graves disease. In: Robertson RP, ed. DeGroot's Endocrinology. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 71.

    Schedule An Appointment

    Contact Atlanta Obsetrics and Gynaecology at The Womens Center Millennium Hospital - 404-ATL-BABY

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    Review Date: 2/28/2024

    Reviewed By: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.