Immunodeficiency disorders
Definition
Immunodeficiency disorders occur when the body's is reduced or absent.
Causes
The immune system is made up of lymphoid tissue in the body, which includes:
Proteins and cells in the blood are also part of the immune system.
The immune system helps protect the body from harmful substances called . Examples of antigens include bacteria, viruses, , cells, and foreign blood or tissues from another person or species.
When the immune system detects an antigen, it responds by activating cells known as T lymphocytes, which interact with cells known as B lymphocytes. The B cells lead to production of proteins called that destroy the harmful substances. The immune system response also involves a process called phagocytosis. During this process, certain white blood cells swallow and destroy bacteria and other foreign substances. Proteins called complement help with this process.
Immunodeficiency disorders may affect any part of the immune system. Most often, these conditions occur when the T or B lymphocytes (or both) do not function normally or your body does not produce enough antibodies.
Inherited immunodeficiency disorders that affect B cells include:
Inherited immunodeficiency disorders that affect T cells may cause repeated Candida (yeast) infections. Inherited combined immunodeficiency affects both T cells and B cells. It may be deadly within the first year of life if it isn't treated early.
People are said to be immunosuppressed when they have an immunodeficiency disorder due to medicines that weaken the immune system. Examples include:
Acquired immunodeficiency may be a complication of diseases such as and malnutrition (especially if the person does not eat enough protein). Many cancers may also cause immunodeficiency.
People who have had their have an acquired immunodeficiency, and are at higher risk for infection by certain bacteria that the spleen would normally help fight. People with diabetes are also at higher risk for certain infections.
As you get older, the immune system becomes less effective. Immune system tissues (especially lymphoid tissue such as the thymus) shrink, and the number and activity of white blood cells drop.
The following are diseases of the immune system that can prevent it from functioning normally:
Symptoms
Your health care provider might think you have an immunodeficiency disorder if you have:
Other signs include:
Symptoms depend on the disorder. For example, those with combined with low levels of certain IgG subclasses are likely to have problems involving the lungs, sinuses, ears, throat, and digestive tract. People with disorders of their T cells also may be more likely to develop severe fungal infections.
Exams and Tests
Tests used to help diagnose an immunodeficiency disorder may include:
Treatment
The goal of treatment is to prevent infections and treat any disease and infections that do develop.
If you have a weakened immune system, you should avoid contact with persons who have infections or contagious disorders. You may have to avoid people who have been vaccinated with live virus vaccines within the past 2 weeks.
If you develop an infection, your provider will treat you aggressively. This may involve long-term use of antibiotic or antifungal drugs to prevent infections from coming back.
Interferon is used to treat viral infections and some types of cancer. It is a medicine that makes the immune system work better.
Persons with HIV/AIDS may take combinations of drugs to reduce the amount of HIV in their immune systems and improve their immunity.
People who are going to have a planned spleen removal should be vaccinated 2 weeks before the surgery against bacteria such as Streptococcus pneumonia and Haemophilus influenzae. People who haven't been previously vaccinated or have no known immunity should also receive the , and vaccines. In addition, it is also recommended that people get the vaccine series or a booster shot as needed.
People who will undergo cancer chemotherapy should get inactivated vaccines 2 weeks prior to the initiation of therapy. They should receive live vaccines 4 weeks prior to the initiation of therapy.
may be used to treat certain immunodeficiency conditions.
Passive immunity (receiving antibodies produced by another person or animal) may sometimes be recommended to prevent illness after you have been exposed to certain bacteria or viruses.
People with low or absent levels of certain immunoglobulins may be helped with intravenous immunoglobulin (IVIG), given through a vein.
Outlook (Prognosis)
Some immunodeficiency disorders are mild and cause illness from time to time. Others are severe and may be fatal. Immunosuppression caused by medicines often goes away once the medicine is stopped.
Possible Complications
Complications of immunodeficiency disorders may include:
When to Contact a Medical Professional
Contact your provider right away if you are on chemotherapy or corticosteroids and you develop:
Go to the emergency room or call your local emergency number (such as 911) if you have a stiff neck and headache with the fever.
Contact your provider if you have repeated yeast infections or oral .
Prevention
There is no known way to prevent inherited immunodeficiency disorders. If you have a family history of immunodeficiency disorders, you might want to seek genetic counseling.
and avoiding the sharing of body fluids may help prevent HIV/AIDS. Ask your provider if a medicine called Truvada is right for you to prevent HIV infection.
Good nutrition may prevent acquired immunodeficiency caused by malnutrition.
References
Abbas AK, Lichtman AH, Pillai S. Primary and acquired immunodeficiencies. In: Abbas AK, Lichtman AH, Pillai S, eds. Cellular and Molecular Immunology. 10th ed. Philadelphia, PA: Elsevier; 2022:chap 21.
Bonanni P, Grazzini M, Niccolai G, et al. Recommended vaccinations for asplenic and hyposplenic adult patients. Hum Vaccin Immunother. 2017;13(2):359-368. PMID: 27929751 pubmed.ncbi.nlm.nih.gov/27929751/.
Cunningham-Rundles C. Primary immunodeficiency diseases. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 231.
Review Date: 3/31/2024
Reviewed By: Deborah Pedersen, MD, MS, Allergy & Asthma Care, PC, Taunton, MA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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