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Ganglioneuroblastoma

Definition

Ganglioneuroblastoma is an intermediate tumor that arises from nerve tissues. An intermediate tumor is one that is between (slow-growing and unlikely to spread) and (fast-growing, aggressive, and likely to spread).

Causes

Ganglioneuroblastoma mostly occurs in children ages 2 to 4 years. The tumor affects boys and girls equally. It occurs rarely in adults. Tumors of the nervous system have different degrees of differentiation. This is based on how the tumor cells look under the microscope. It can predict whether or not they are likely to spread.

Benign tumors are less likely to spread. Malignant tumors are aggressive, grow quickly, and often spread. A is less malignant in nature. A (occurring in children over 1 year old) is usually malignant.

A ganglioneuroblastoma may be only in one area or it may be widespread, but it is usually less aggressive than a neuroblastoma. The cause is unknown.

Symptoms

Most commonly, a lump can be felt in the abdomen with tenderness.

This tumor may also occur at other sites, including:

  • Chest cavity
  • Neck
  • Legs

    • Exams and Tests

    The health care provider may do the following tests:

  • Fine-needle aspiration of the tumor
  • Bone marrow and
  • Bone scan
  • of the affected area
  • of the affected area
  • Special blood and urine tests
  • Surgical biopsy to confirm diagnosis

    • Treatment

    Depending on the type of tumor, treatment can involve surgery, and possibly chemotherapy and radiation therapy.

    Because these tumors are rare, they should be treated in a specialized center by experts who have experience with them.

    Support Groups

    More information and support for children with ganglioneuroblastoma and their families can be found at:

  • Children's Oncology Group -- www.childrensoncologygroup.org
  • The Neuroblastoma Children's Cancer Society -- neuroblastomachildrenscancersociety.org/

    • Outlook (Prognosis)

    The outlook depends on how far the tumor has spread, and whether some areas of the tumor contain more aggressive cancer cells.

    Possible Complications

    Complications that may result include:

  • Complications of surgery, , or
  • Spread of the tumor into surrounding areas

    • When to Contact a Medical Professional

    Contact your provider if you feel a lump or growth on your child's body. Make sure children receive routine examinations as part of their well-child care.

    References

    Hernandez Tejada FN, Harrison DJ. Neuroblastoma. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 547.

    Myers JL. Mediastinum. In: Goldblum JR, Lamps LW, McKenney JK, Myers JL, eds. Rosai and Ackerman's Surgical Pathology. 11th ed. Philadelphia, PA: Elsevier; 2018:chap 12.

    Schedule An Appointment

    Contact Atlanta Obsetrics and Gynaecology at The Womens Center Millennium Hospital - 404-ATL-BABY

    GO

    Review Date: 12/31/2023

    Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.