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Gastric tissue biopsy and culture

Definition

Gastric tissue is the removal of stomach tissue for examination. A culture is a laboratory test that examines the tissue sample for bacteria and other organisms that can cause disease.

How the Test is Performed

The tissue sample is removed during a procedure called . It is done with a flexible tube with a small camera (flexible endoscope) at the end. The scope is inserted down the throat into the stomach.

Your health care provider sends the tissue sample to a laboratory where it is examined for signs of cancer, certain infections, or other problems.

How to Prepare for the Test

Follow instructions on how to prepare for the procedure. You will likely be asked not to eat or drink anything for 6 to 12 hours before the procedure.

How the Test will Feel

Your provider will tell you what to expect during the procedure.

Why the Test is Performed

This test may be done to diagnose a or the cause of other stomach symptoms. These symptoms may include:

  • Loss of appetite or weight loss
  • Nausea and vomiting
  • Pain in the upper part of the belly
  • Black stools
  • Vomiting blood or coffee ground-like material

    • A gastric tissue biopsy and culture can help detect:

  • Cancer
  • Infections, most commonly , the bacteria that can cause stomach or intestinal ulcers

    • Normal Results

    A gastric tissue biopsy is normal if it does not show cancer, other damage to the lining of the stomach, or signs of organisms that cause infection.

    A gastric tissue culture may be considered normal if it does not show certain bacteria. Stomach acids normally prevent too much bacteria from growing.

    What Abnormal Results Mean

    Abnormal results may be due to:

  • , when the lining of the stomach becomes inflamed or swollen
  • Helicobacter pylori infection

    • Risks

    Your provider will discuss the risks of the upper endoscopy procedure with you.

    References

    Feldman M, Jensen PJ, Howden CW. Gastritis and gastropathy. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 52.

    Sugumar A, Vargo JJ. Preparation for and complications of GI endoscopy. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 42.

    Schedule An Appointment

    Contact Atlanta Obsetrics and Gynaecology at The Womens Center Millennium Hospital - 404-ATL-BABY

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    Review Date: 10/13/2023

    Reviewed By: Linda J. Vorvick, MD, Clinical Professor, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington, Seattle, WA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.