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Cryotherapy for the skin

Cryotherapy is a method of superfreezing tissue in order to destroy it. This article discusses cryotherapy of the skin.

Cryotherapy is done using a cotton swab that has been dipped into liquid nitrogen or a probe that has liquid nitrogen flowing through it.

The procedure is done in your health care provider's office. It usually takes less than a minute.

The freezing may cause some discomfort. Your provider may apply a numbing medicine to the area first.

Cryotherapy or cryosurgery may be used to:

  • Remove
  • Destroy precancerous skin lesions (actinic keratoses or solar keratoses)
  • In rare cases, cryotherapy is used to treat some skin cancers. But, skin that is destroyed during cryotherapy cannot be examined under a microscope. A skin biopsy is needed if your provider wants to check the lesion for signs of cancer.

    Cryotherapy risks include:

  • Blisters and ulcers, leading to pain and infection
  • Scarring, especially if the freezing was prolonged or deeper areas of the skin were affected
  • Changes in skin color (skin turns white)
  • Cryotherapy works well for many people. Some skin lesions, especially warts, may need to be treated more than once.

    The treated area may look red after the procedure. A blister will often form within a few hours. It may appear clear or have a red or purple color.

    You may have a little pain for up to 3 days.

    Most of the time, no special care is needed during healing. The area should be washed gently once or twice a day and kept clean. A bandage or dressing should only be needed if the area rubs against clothes or may be easily injured.

    A scab forms and will usually peel away within 1 to 3 weeks, depending on the area treated.

    Call your provider if:

  • There are signs of infection such as redness, swelling, or drainage.
  • The skin lesion is not gone after it has healed.
  • Dinulos JGH. Dermatologic surgical procedures. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 27.

    Pasquali P. Cryosurgery. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 4th ed. Philadelphia, PA: Elsevier; 2018:chap 138.

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    Contact Atlanta Obsetrics and Gynaecology at The Womens Center Millennium Hospital - 404-ATL-BABY

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    Review Date: 7/1/2023

    Reviewed By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.