Treats cancer, including liposarcoma and leiomyosarcoma.
Brand Name(s):
Yondelis
There may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to trabectedin, or if you are pregnant or breastfeeding.
How to Use This Medicine:
Injectable
Your doctor will prescribe your dose and schedule. This medicine is given through an IV placed in a vein.
You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Some foods and medicines can affect how trabectedin works. Tell your doctor if you are using boceprevir, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lopinavir, nefazodone, nelfinavir, phenobarbital, posaconazole, rifampin, ritonavir, saquinavir, St John's wort, telaprevir, telithromycin, or voriconazole.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment and for at least 2 months after your last dose. Men who are receiving this medicine should use effective birth control during treatment and for at least 5 months after your final dose.
Tell your doctor if you have kidney disease, liver disease, or heart disease.
This medicine may cause the following problems:
Severely low white blood cells counts, which may lead to serious or life-threatening infection
Rhabdomyolysis (severe muscle problem)
Liver damage
Damage to the heart muscle, heart failure
Damage to the skin around the injection site
Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fever, chills, cough, sore throat, and body aches
Pain, itching, burning, swelling, or redness where the needle is placed
Rapid weight gain, swelling in your hands, ankles, or feet, chest pain, trouble breathing, unusual tiredness
Severe muscle pain, tenderness, or weakness
Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
Headache
Loss of appetite
Nausea, vomiting, constipation, diarrhea
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 6/6/2024
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